Glutathione dosage reference: typical range 200 – 600 mg, 2–3×/week (IV/IM) or daily (SubQ low-dose), cycle 8–12 weeks on, 2–4 weeks off. Titration chart…
The principal endogenous antioxidant — a tripeptide of glutamate, cysteine, and glycine. Central to detoxification, redox balance, and immune function; cellular levels decline with age and oxidative stress.
Published protocol literature for Glutathione describes a typical range of 200 – 600 mg, dosed 2–3×/week (iv/im) or daily (subq low-dose), over a cycle of 8–12 weeks on, 2–4 weeks off.
| Parameter | Reported value |
|---|---|
| Typical dose range | 200 – 600 mg |
| Frequency | 2–3×/week (IV/IM) or daily (SubQ low-dose) |
| Cycle length | 8–12 weeks on, 2–4 weeks off |
| Route | Subcutaneous injection (most published protocols) |
| Diluent | Bacteriostatic water |
| Commonly stacked with | NAD+ (redox + energy), Vitamin C (regenerates GSH), Epitalon (longevity) |
Protocols are usually titrated rather than started at the top of the range. The tiers below reflect how Glutathione dosing is commonly stepped in the published protocol literature.
| Tier | Dose | Frequency | Notes |
|---|---|---|---|
| Beginner | 200 mg | 2×/week | Baseline antioxidant support |
| Intermediate | 400 mg | 2–3×/week | Detox and skin-clarity protocols |
| Advanced | 600 mg | 3×/week | High oxidative load; clinical settings |
Concentration in mcg/mL equals vial milligrams multiplied by 1000, divided by the millilitres of bacteriostatic water added. Volume per dose in mL equals the target dose in mcg divided by that concentration. On a U-100 insulin syringe, multiply the volume in mL by 100 to read the units.
| Vial | Bacteriostatic water | Resulting concentration |
|---|---|---|
| 2 mg vial | 1 mL bacteriostatic water | 2,000 mcg/mL |
| 5 mg vial | 2 mL bacteriostatic water | 2,500 mcg/mL |
| 10 mg vial | 2 mL bacteriostatic water | 5,000 mcg/mL |
| State | Conditions | Shelf life |
|---|---|---|
| Lyophilized (Powder) | Refrigerate 2–8°C (36–46°F) or freeze | 12–24 months refrigerated; longer frozen |
| Reconstituted | Refrigerate 2–8°C only; no freezing | 21–30 days typically |
| In Transit | Insulated packaging; ice packs | Minimize time; avoid heat exposure |
| MK-677 (Oral) | Room temp okay; cool/dry preferred | Per manufacturer; typically 12+ months |
Dose ranges on this page summarise published research and practitioner protocol literature for Glutathione. They are a reference, not medical direction. All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.
Published protocol literature for Glutathione generally describes 200 – 600 mg, administered 2–3×/week (iv/im) or daily (subq low-dose). Individual protocols vary and should be set by a licensed practitioner.
2–3×/week (IV/IM) or daily (SubQ low-dose). Frequency is driven by half-life, so shorter-acting compounds are dosed more often.
Typical cycle length reported is 8–12 weeks on, 2–4 weeks off. Cycling exists to limit receptor desensitisation and to create assessment windows, not as a fixed rule.
2mg → 1ml bacteriostatic water; 5mg → 2ml bacteriostatic water; 10mg → 2ml bacteriostatic water. Concentration in mcg/mL equals vial milligrams times 1000 divided by millilitres of bacteriostatic water.
Both are central to redox biology — NAD+ drives energy and repair pathways while glutathione handles antioxidant defense, so they appear together in longevity research.