MK-677 dosage reference: typical range 10–25 mg, Once daily (PM), cycle 8–16 weeks on, 4–8 weeks off. Titration chart, reconstitution math and storage.
Non-peptide oral growth hormone secretagogue that mimics ghrelin. Convenient alternative to injectable GH peptides; provides 24-hour GH elevation with single daily dose.
Published protocol literature for MK-677 describes a typical range of 10–25 mg, dosed once daily (pm), over a cycle of 8–16 weeks on, 4–8 weeks off. Reported half-life: ~24 hours.
| Parameter | Reported value |
|---|---|
| Typical dose range | 10–25 mg |
| Frequency | Once daily (PM) |
| Cycle length | 8–16 weeks on, 4–8 weeks off |
| Half-life | ~24 hours |
| Route | Subcutaneous injection (most published protocols) |
| Diluent | Bacteriostatic water |
| Commonly stacked with | Ipamorelin (non-injectable GH synergy), Cardarine (endurance) |
Protocols are usually titrated rather than started at the top of the range. The tiers below reflect how MK-677 dosing is commonly stepped in the published protocol literature.
| Tier | Dose | Frequency | Notes |
|---|---|---|---|
| Beginner | 10 mg | Once daily (PM) | Easy start; expect appetite increase |
| Intermediate | 15–20 mg | Once daily | Solid gains; watch water retention |
| Advanced | 25 mg | Once daily | Maximum effects; monitor prolactin, fasting glucose |
Concentration in mcg/mL equals vial milligrams multiplied by 1000, divided by the millilitres of bacteriostatic water added. Volume per dose in mL equals the target dose in mcg divided by that concentration. On a U-100 insulin syringe, multiply the volume in mL by 100 to read the units.
| Vial | Bacteriostatic water | Resulting concentration |
|---|---|---|
| Oral capsule / solution — no reconstitution required | — | — |
| State | Conditions | Shelf life |
|---|---|---|
| Lyophilized (Powder) | Refrigerate 2–8°C (36–46°F) or freeze | 12–24 months refrigerated; longer frozen |
| Reconstituted | Refrigerate 2–8°C only; no freezing | 21–30 days typically |
| In Transit | Insulated packaging; ice packs | Minimize time; avoid heat exposure |
| MK-677 (Oral) | Room temp okay; cool/dry preferred | Per manufacturer; typically 12+ months |
Dose ranges on this page summarise published research and practitioner protocol literature for MK-677. They are a reference, not medical direction. All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.
Published protocol literature for MK-677 generally describes 10–25 mg, administered once daily (pm). Individual protocols vary and should be set by a licensed practitioner.
Once daily (PM). Frequency is driven by half-life — MK-677 has a reported half-life of ~24 hours, so shorter-acting compounds are dosed more often.
Typical cycle length reported is 8–16 weeks on, 4–8 weeks off. Cycling exists to limit receptor desensitisation and to create assessment windows, not as a fixed rule.
Oral capsule / solution — no reconstitution required. Concentration in mcg/mL equals vial milligrams times 1000 divided by millilitres of bacteriostatic water.
Technically no — it is a small-molecule ghrelin mimetic, but it is commonly grouped with peptides because it targets the same GH pathway.
Yes. Oral availability is one of its main research distinctions versus injectable secretagogues like Ipamorelin.