Glutathione

Glutathione is a tripeptide (glutamate-cysteine-glycine) and the principal endogenous antioxidant inside cells. It is central to oxidative-stress…

The body's master intracellular antioxidant — extensively studied for cellular defense.

Glutathione is a tripeptide (glutamate-cysteine-glycine) and the principal endogenous antioxidant inside cells. It is central to oxidative-stress, detoxification, and immune-related research.

Overview

Glutathione is a tripeptide composed of glutamate, cysteine, and glycine. It is the principal endogenous antioxidant inside cells and a key participant in detoxification and immune-related research.

Mechanism of action

Donates electrons to neutralize reactive oxygen species and conjugates xenobiotics for phase-II detoxification.

Researched applications

• Oxidative-stress research
• Hepatic and detoxification studies
• Immune and skin research

Quick facts

Property	Detail
Class	Tripeptide antioxidant
Sequence	γ-Glu-Cys-Gly
Molecular weight	~307 Da
Routes (research)	IV, subcutaneous, nebulized

Other longevity & cellular peptides

Glutathione sits in our longevity & cellular category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.

• NAD+ — Foundational cellular coenzyme studied for energy metabolism and longevity.
• MOTS-c — Mitochondrial-encoded peptide studied for metabolic regulation and exercise mimicry.
• Epitalon — Tetrapeptide studied for telomerase activity and circadian/pineal research.
• DSIP — Nonapeptide first isolated from cerebral venous blood — studied for delta-wave sleep and stress-response research.

Glutathione head-to-head

• NAD+ vs Glutathione: Two flagship 'wellness IV' molecules with completely different jobs — coenzyme energy metabolism vs master antioxidant detoxification.

Storage and shelf life

State	Conditions	Shelf life
Lyophilized (Powder)	Refrigerate 2–8°C (36–46°F) or freeze	12–24 months refrigerated; longer frozen
Reconstituted	Refrigerate 2–8°C only; no freezing	21–30 days typically
In Transit	Insulated packaging; ice packs	Minimize time; avoid heat exposure
MK-677 (Oral)	Room temp okay; cool/dry preferred	Per manufacturer; typically 12+ months

Sources

• Glutathione: overview of its protective roles, measurement, and biosynthesis — PubMed / NCBI (accessed 2026-06-13): https://pubmed.ncbi.nlm.nih.gov/19061483/

Review status

This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.

Important

All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.

Frequently asked questions

Why is glutathione often discussed alongside NAD+?

Both are central to redox biology — NAD+ drives energy and repair pathways while glutathione handles antioxidant defense, so they appear together in longevity research.