MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. Research positions it as a metabolic regulator that activates AMPK and shows…
Mitochondrial-encoded peptide studied for metabolic regulation and exercise mimicry.
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. Research positions it as a metabolic regulator that activates AMPK and shows exercise-mimetic effects in animal models.
MOTS-c is one of a small family of mitochondrial-derived peptides. It has attracted significant longevity-research interest for its role in cellular energy homeostasis and insulin sensitivity.
Activates AMPK signaling and modulates folate-methionine metabolism, with downstream effects on glucose handling and mitochondrial function.
| Property | Detail |
|---|---|
| Class | Mitochondrial-derived peptide |
| Sequence length | 16 amino acids |
| Typical research route | Subcutaneous |
Reported half-life: Short (minutes, free peptide).
MOTS-c sits in our longevity & cellular category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.
| State | Conditions | Shelf life |
|---|---|---|
| Lyophilized (Powder) | Refrigerate 2–8°C (36–46°F) or freeze | 12–24 months refrigerated; longer frozen |
| Reconstituted | Refrigerate 2–8°C only; no freezing | 21–30 days typically |
| In Transit | Insulated packaging; ice packs | Minimize time; avoid heat exposure |
| MK-677 (Oral) | Room temp okay; cool/dry preferred | Per manufacturer; typically 12+ months |
This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.
All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.
It is encoded by mitochondrial DNA rather than nuclear DNA — one of only a handful of known mitochondrial-derived peptides.