TB-500

TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (TB4), a naturally occurring protein. It is studied for actin regulation, cell migration, and…

Synthetic fragment of Thymosin Beta-4 studied for cellular repair and migration.

TB-500 is a synthetic peptide fragment of Thymosin Beta-4 (TB4), a naturally occurring protein. It is studied for actin regulation, cell migration, and wound healing — and is the most common stack partner for BPC-157 in recovery research.

Overview

TB-500 is a synthetic peptide fragment of the naturally occurring protein Thymosin Beta-4 (TB4). Preclinical research focuses on its role in actin regulation, cell migration, and wound-healing pathways.

Mechanism of action

TB-500 binds actin and is implicated in cell migration, proliferation, and the upregulation of repair-related signaling in injured tissue.

Researched applications

Quick facts

PropertyDetail
ClassSynthetic TB4 fragment
Sequence length7 amino acids (active fragment)
Half-lifeSeveral days (circulation, rodent)
Typical research dose2–5 mg/week (preclinical loading)
StorageLyophilized: freezer. Reconstituted: 2–8 °C
DiluentBacteriostatic water

Half-life

Reported half-life: Several days in circulation (animal models).

Commonly researched alongside

Other healing & recovery peptides

TB-500 sits in our healing & recovery category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.

TB-500 head-to-head

Storage and shelf life

StateConditionsShelf life
Lyophilized (Powder)Refrigerate 2–8°C (36–46°F) or freeze12–24 months refrigerated; longer frozen
ReconstitutedRefrigerate 2–8°C only; no freezing21–30 days typically
In TransitInsulated packaging; ice packsMinimize time; avoid heat exposure
MK-677 (Oral)Room temp okay; cool/dry preferredPer manufacturer; typically 12+ months

Sources

Review status

This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.

Important

All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.

Frequently asked questions

What's the difference between TB-500 and Thymosin Beta-4?

TB-500 is a synthetic fragment of the full TB4 protein. It contains the active region most associated with repair-pathway research.

Is TB-500 legal to purchase?

TB-500 is sold in the U.S. for research, investigational, or licensed professional use only. It is not FDA-approved for human use.