Sermorelin

Sermorelin is a 29-amino-acid GHRH analog representing the bioactive fragment of natural growth hormone–releasing hormone. It has one of the longest track…

GHRH (1-29) analog used in long-running clinical and research literature.

Sermorelin is a 29-amino-acid GHRH analog representing the bioactive fragment of natural growth hormone–releasing hormone. It has one of the longest track records of any GH-supporting peptide in clinical-research literature.

Overview

Sermorelin is a 29-amino-acid GHRH analog representing the bioactive fragment of natural growth hormone–releasing hormone. It has one of the longest track records in clinical-research literature among GH-supporting peptides.

Mechanism of action

Activates pituitary GHRH receptors to stimulate natural GH secretion.

Researched applications

• Endogenous GH support research
• Sleep and recovery studies

Quick facts

Property	Detail
Class	GHRH (1-29) analog
Sequence length	29 amino acids
Half-life	10–20 minutes
Storage	Lyophilized: freezer. Reconstituted: 2–8 °C

Half-life

Reported half-life: 10–20 minutes.

Commonly researched alongside

• Ipamorelin (modern preferred pair)

Other growth hormone support peptides

Sermorelin sits in our growth hormone support category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.

• CJC-1295 — A growth hormone–releasing hormone analog studied for endogenous GH support.
• Ipamorelin — Selective ghrelin-receptor agonist studied for clean GH pulses.
• MK-677 — Orally-active small-molecule ghrelin-receptor agonist studied for sustained GH/IGF-1 elevation.

Sermorelin head-to-head

• Sermorelin vs CJC-1295: Two GHRH analogs from different eras. Sermorelin is the original GHRH (1-29) fragment; CJC-1295 is the engineered, longer-acting evolution.
• Sermorelin vs Ipamorelin: GHRH analog vs GHRP: two ways to raise growth hormone, hitting two different receptors. Why the answer is almost always 'both'.

Storage and shelf life

State	Conditions	Shelf life
Lyophilized (Powder)	Refrigerate 2–8°C (36–46°F) or freeze	12–24 months refrigerated; longer frozen
Reconstituted	Refrigerate 2–8°C only; no freezing	21–30 days typically
In Transit	Insulated packaging; ice packs	Minimize time; avoid heat exposure
MK-677 (Oral)	Room temp okay; cool/dry preferred	Per manufacturer; typically 12+ months

Sources

• Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? — PubMed / NCBI (accessed 2026-06-13): https://pubmed.ncbi.nlm.nih.gov/19951471/

Review status

This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.

Important

All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.

Frequently asked questions

How is Sermorelin different from CJC-1295?

Both target the GHRH receptor. CJC-1295 is engineered for greater stability and longer action than the parent Sermorelin molecule.