NAD+

NAD+ is a coenzyme central to cellular energy production, DNA repair, and sirtuin signaling. Endogenous NAD+ declines with age, making it a focal point of…

Foundational cellular coenzyme studied for energy metabolism and longevity.

NAD+ is a coenzyme central to cellular energy production, DNA repair, and sirtuin signaling. Endogenous NAD+ declines with age, making it a focal point of longevity and metabolic research.

Overview

NAD+ is a coenzyme central to cellular energy production, DNA repair, and sirtuin signaling. Endogenous NAD+ declines with age, which has made it a focal point of longevity and metabolic research.

Mechanism of action

Acts as an electron carrier in redox reactions and a substrate for sirtuin and PARP enzyme families involved in DNA repair and metabolic regulation.

Researched applications

• Cellular energy and mitochondrial research
• Longevity pathway studies (sirtuins, PARPs)
• Cognitive and metabolic research

Quick facts

Property	Detail
Class	Pyridine nucleotide coenzyme
Molecular weight	~663 Da
Routes (research)	IV, subcutaneous, intranasal
Storage	Lyophilized: freezer, light-protected

Other longevity & cellular peptides

NAD+ sits in our longevity & cellular category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.

• Glutathione — The body's master intracellular antioxidant — extensively studied for cellular defense.
• MOTS-c — Mitochondrial-encoded peptide studied for metabolic regulation and exercise mimicry.
• Epitalon — Tetrapeptide studied for telomerase activity and circadian/pineal research.
• DSIP — Nonapeptide first isolated from cerebral venous blood — studied for delta-wave sleep and stress-response research.

NAD+ head-to-head

• NAD+ vs Glutathione: Two flagship 'wellness IV' molecules with completely different jobs — coenzyme energy metabolism vs master antioxidant detoxification.

Storage and shelf life

State	Conditions	Shelf life
Lyophilized (Powder)	Refrigerate 2–8°C (36–46°F) or freeze	12–24 months refrigerated; longer frozen
Reconstituted	Refrigerate 2–8°C only; no freezing	21–30 days typically
In Transit	Insulated packaging; ice packs	Minimize time; avoid heat exposure
MK-677 (Oral)	Room temp okay; cool/dry preferred	Per manufacturer; typically 12+ months

Sources

• NAD+ in aging, metabolism, and neurodegeneration — Science / PubMed (accessed 2026-06-13): https://pubmed.ncbi.nlm.nih.gov/26785480/

Review status

This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.

Important

All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.

Frequently asked questions

Is NAD+ a peptide?

Strictly, NAD+ is a coenzyme rather than a peptide, but it is commonly stocked alongside research peptides in longevity-focused inventories.