KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). Research focuses on its anti-inflammatory activity in gut, skin, and…
Tripeptide fragment of α-MSH studied for its anti-inflammatory signaling.
KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). Research focuses on its anti-inflammatory activity in gut, skin, and wound-healing models, without the pigmentation effects of the full α-MSH molecule.
KPV is the three–amino-acid tail (lysine-proline-valine) of α-MSH. Isolating this fragment preserves much of the parent hormone's anti-inflammatory signaling while dropping the melanocortin-receptor activity responsible for pigmentation. Published work covers colitis models, topical skin studies, and wound repair, which is why it commonly appears in aesthetic and recovery blends such as KLOW.
Appears to act intracellularly, interfering with NF-κB and interleukin-1 signaling pathways that drive pro-inflammatory cytokine production, rather than through melanocortin receptor activation.
| Property | Detail |
|---|---|
| Class | Tripeptide α-MSH fragment |
| Sequence | Lys-Pro-Val |
| Molecular weight | ~342 Da |
| Routes (research) | Subcutaneous, oral, topical |
| Storage | Lyophilized: freezer. Reconstituted: 2–8 °C |
KPV sits in our healing & recovery category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.
| State | Conditions | Shelf life |
|---|---|---|
| Lyophilized (Powder) | Refrigerate 2–8°C (36–46°F) or freeze | 12–24 months refrigerated; longer frozen |
| Reconstituted | Refrigerate 2–8°C only; no freezing | 21–30 days typically |
| In Transit | Insulated packaging; ice packs | Minimize time; avoid heat exposure |
| MK-677 (Oral) | Room temp okay; cool/dry preferred | Per manufacturer; typically 12+ months |
This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.
All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.
No. KPV is the non-pigmenting fragment of α-MSH — the portion of the molecule responsible for melanocortin receptor-driven pigmentation is not part of the tripeptide.
KLOW pairs repair peptides (BPC-157, TB-500) and a collagen-focused copper peptide (GHK-Cu) with KPV's anti-inflammatory action, so the blend addresses both tissue rebuilding and the inflammatory environment around it.
Both appear in the literature. Oral and topical delivery are common in gut and skin research; subcutaneous administration is typical in systemic recovery research.