DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide originally isolated in 1977 from the cerebral venous blood of sleeping rabbits…
Nonapeptide first isolated from cerebral venous blood — studied for delta-wave sleep and stress-response research.
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide originally isolated in 1977 from the cerebral venous blood of sleeping rabbits. Research explores its role in slow-wave (delta) sleep architecture, HPA-axis modulation, and stress resilience.
DSIP is a 9-amino-acid peptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first characterized by Schoenenberger and Monnier in Switzerland. Unlike sedative hypnotics, DSIP does not act on GABA receptors — its mechanism remains under active investigation, with published work spanning sleep neurophysiology, endocrinology, and stress-response research.
Mechanism is not fully characterized. Research suggests modulation of hypothalamic-pituitary-adrenal (HPA) axis signaling and interaction with somatostatin and corticotropin pathways rather than direct GABA-ergic action.
| Property | Detail |
|---|---|
| Class | Naturally occurring nonapeptide |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Discovered | 1977 (Schoenenberger & Monnier, Switzerland) |
| Half-life | ~7 minutes plasma |
| Common research dose | 100–300 mcg (subcutaneous) |
| Timing | Evening, 30–60 min before sleep window |
Typical research reconstitution: 2 mL bacteriostatic water into a 5 mg vial → 2.5 mg/mL. A 0.1 mL draw = 250 mcg. Subcutaneous administration is most commonly reported in the sleep-research literature.
Reported half-life: ~7 minutes (plasma) — very short.
DSIP sits in our longevity & cellular category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.
| State | Conditions | Shelf life |
|---|---|---|
| Lyophilized (Powder) | Refrigerate 2–8°C (36–46°F) or freeze | 12–24 months refrigerated; longer frozen |
| Reconstituted | Refrigerate 2–8°C only; no freezing | 21–30 days typically |
| In Transit | Insulated packaging; ice packs | Minimize time; avoid heat exposure |
| MK-677 (Oral) | Room temp okay; cool/dry preferred | Per manufacturer; typically 12+ months |
This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.
All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.
Delta Sleep-Inducing Peptide — named for its ability to induce delta-wave (deep, slow-wave) EEG activity in early animal studies.
Sedatives (benzodiazepines, Z-drugs) act on GABA receptors and force sleep pharmacologically. DSIP is a naturally occurring peptide studied for modulating sleep architecture and the HPA stress axis, not direct sedation.
Published sleep-research protocols usually administer DSIP subcutaneously 30–60 minutes before the intended sleep window, given its very short (~7-minute) plasma half-life.
Published protocols most commonly report 100–300 mcg per administration. Doses vary by study endpoint (sleep-architecture, stress-response, chronobiology).
No. DSIP is a research peptide with no FDA-approved therapeutic indication. It is used strictly for laboratory research.