CJC-1295

CJC-1295 (no-DAC) is a 30-amino-acid GHRH analog that triggers pulsatile growth-hormone release from the pituitary. It is most commonly paired with…

A growth hormone–releasing hormone analog studied for endogenous GH support.

CJC-1295 (no-DAC) is a 30-amino-acid GHRH analog that triggers pulsatile growth-hormone release from the pituitary. It is most commonly paired with Ipamorelin in research protocols for a stronger combined GH pulse.

Overview

CJC-1295 is a synthetic analog of growth hormone–releasing hormone (GHRH). The no-DAC version produces a pulsatile GH release pattern and is frequently paired with a ghrelin-receptor peptide such as Ipamorelin in research protocols.

Mechanism of action

Binds the GHRH receptor on the pituitary to stimulate endogenous growth hormone release while preserving natural pulsatility.

Researched applications

• Endogenous GH and IGF-1 release studies
• Body-composition and recovery research
• Sleep-quality model research

Quick facts

Property	Detail
Class	GHRH analog
Sequence length	30 amino acids
Half-life (no-DAC)	~30 minutes
Typical research dose	100 mcg with Ipamorelin (preclinical pair)
Storage	Lyophilized: freezer. Reconstituted: 2–8 °C

Half-life

Reported half-life: About 30 minutes (no-DAC); several days (DAC variant).

Commonly researched alongside

• Ipamorelin (the canonical GHRH + GHRP pair)
• Sermorelin (alternate GHRH backbone)

Other growth hormone support peptides

CJC-1295 sits in our growth hormone support category. These are the other compounds in the same category, useful when you are deciding which reference page to read next.

• Ipamorelin — Selective ghrelin-receptor agonist studied for clean GH pulses.
• Sermorelin — GHRH (1-29) analog used in long-running clinical and research literature.
• MK-677 — Orally-active small-molecule ghrelin-receptor agonist studied for sustained GH/IGF-1 elevation.

CJC-1295 head-to-head

• CJC-1295 vs Ipamorelin: The canonical GHRH + GHRP pair — how each works alone, why they are almost always studied together, and what the no-DAC distinction means.
• Sermorelin vs CJC-1295: Two GHRH analogs from different eras. Sermorelin is the original GHRH (1-29) fragment; CJC-1295 is the engineered, longer-acting evolution.

Storage and shelf life

State	Conditions	Shelf life
Lyophilized (Powder)	Refrigerate 2–8°C (36–46°F) or freeze	12–24 months refrigerated; longer frozen
Reconstituted	Refrigerate 2–8°C only; no freezing	21–30 days typically
In Transit	Insulated packaging; ice packs	Minimize time; avoid heat exposure
MK-677 (Oral)	Room temp okay; cool/dry preferred	Per manufacturer; typically 12+ months

Sources

• CJC-1295: a long-acting GHRH analog — PubMed / NCBI (accessed 2026-06-13): https://pubmed.ncbi.nlm.nih.gov/16352683/

Review status

This reference page was last reviewed on 2026-06-13 by the Clarity Wellness editorial team.

Important

All peptide products referenced are intended solely for research, investigational, or licensed professional use. They are not FDA-approved and are not intended to diagnose, treat, cure, or prevent any disease. Consult a licensed medical practitioner before any personal or clinical use.

Frequently asked questions

Why pair CJC-1295 with Ipamorelin?

They act on complementary pathways — CJC-1295 on the GHRH receptor and Ipamorelin on the ghrelin/GHS-R receptor — producing a stronger synergistic GH pulse in research models.

What's the difference between DAC and no-DAC CJC-1295?

DAC (Drug Affinity Complex) extends half-life to several days for tonic GH elevation. No-DAC preserves natural pulsatility, which most research protocols prefer.